Chlormethiazole or chlordiazepoxide?

Chlormethiazole or chlordiazepoxide in alcohol detoxification

The alcohol withdrawal syndrome is charac terised by symptoms such as anxiety, insomnia, anorexia, nausea, tremor, sweating and distur bances in coordination. These symptoms tend to occur within 6 to 12 hours of alcohol-dependent patients stopping or reducing their alcohol in take. Less frequently, convulsions, hallucinosis and delirium tremens can occur. Delirium tremens (disturbed orientation...

DRUG INFORMATION QUARTERLY Chlormethiazole or chlordiazepoxide in alcohol detoxification

The alcohol withdrawal syndrome is charac terised by symptoms such as anxiety, insomnia, anorexia, nausea, tremor, sweating and distur bances in coordination. These symptoms tend to occur within 6 to 12 hours of alcohol-dependent patients stopping or reducing their alcohol in take. Less frequently, convulsions, hallucinosis and delirium tremens can occur. Delirium tremens (disturbed orientation...

Attenuation by chlormethiazole

1 In vivo microdialysis has been used to investigate the concentration of various amino acids and lactate in the extracellular fluid of the rat cortex following focal ischaemia, the probe being placed in the core of the infarct area. 2 An ischaemic infarct was produced in the cortex by use of a photochemical dye (Rose Bengal) and light irradiation. There was a marked increase in lactate concent...

Chlormethiazole, sleep, and drug withdrawal.

Chlordiazepoxide dichloro­methane monosolvate

IN THE TITLE COMPOUND (SYSTEMATIC NAME 7-chloro-2-methyl-amino-5-phenyl-3H-1,4-benzodiazepine 4-oxide dichloro-meth-ane monosolvate), C(16)H(14)ClN(3)O·CH(2)Cl(2), the seven-membered ring adopts a boat conformation with the CH(2) group as the prow and the two aromatic C atoms as the stern. The dihedral angle between the benzene rings is 75.25 (6)°. The crystal structure features centrosymmetric...